HUMAN HERPESVIRUSES Ø Infect only humans. Ø Herpesviridae family contains enveloped , double-stranded DNA viruses with large complex genomes. Ø They replicate in the nucleus of a wide range of vertebrate hosts. · Of the more than 100 known herpesviruses, 8 routinely I. STRUCTURE OF HERPESVIRUSES Ø The herpes viruses are large, enveloped viruses that contain double-stranded DNA. Ø The virion is 150 nm in diameter. Ø The DNA core is surrounded by an icosadeltahedral capsid containing 162 capsomeres. Ø This capsid is enclosed by a glycoprotein-containing envelope. Ø Encode several glycoproteins for viral attachment, fusion, and for escaping immune control. Ø As enveloped viruses, the herpesviruses are sensitive to acid, solvents, detergents, and drying. II. ...
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